Endocrine Abstracts

Prolactin is associated with seasonal transitions into and out of anestrus in the mare. The earliest anestrous transitional changes are declining progesterone secretion and a concomitant prolactin decline. Ovarian changes include slowed follicular development and prolonged luteal activity. Dopamine antagonist administration during the autumnal transition prevented a seasonal progesterone decline, suggesting a cause-and-effect between prolactin and progesterone production. The ...

Introduction: 131I-Metaiodobenzylguanidine (131I-MIBG) is used as palliative therapy in patients with metastatic neuroendocrine tumours (NET), but can cause bone marrow suppression, hypothyroidism and renal impairment.Methods: Retrospective case note analysis identified 58 patients treated with between May 1996 and May 2006. We assessed the efficacy and toxicity of 131I-MIBG therapy in 49 of these patients (12men; mean age at diagnosis: 57.4 years; range...

Background: Testosterone is a coronary vasodilator, and improves myocardial ischaemia in men with coronary artery disease. The dilatory mechanism of testosterone is independent of the classical androgen receptor and endothelial-derived vasodilators. The aim of this study was to determine whether testosterone increases cAMP production in vascular smooth muscle cells (VSMCs) derived from the primary culture of rat thoracic aortae or in a VSMC cell line (A7r5).<p class="abste...